Further multi-centre trials are required to verify these findings. CONCLUSIONS: Acute administration of atorvastatin in patients with sepsis may prevent sepsis progression. No difference in adverse events between the two groups was observed (p = 0.238). Plasma cholesterol and albumin creatinine ratios were significantly lower at day 4 in the atorvastatin group (p <0.0001 and p = 0.049 respectively). No significant difference in length of hospital stay, critical care unit admissions, 28-day and 12-month readmissions or mortality was observed. 24% p = 0.007.), with a number needed to treat of 5. Patients in the atorvastatin group had a significantly lower conversion rate to severe sepsis compared to placebo (4% vs. RESULTS: 100 patients were randomized, 49 to the treatment with atorvastatin and 51 to placebo. The primary end-point was the rate of sepsis progressing to severe sepsis during hospitalization. Patients with sepsis were randomized to atorvastatin 40 mg daily or placebo for the duration of their hospital stay up to a maximum of 28-days. METHODS: A single centre phase II randomized double-blind placebo-controlled trial. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in statin nave patients hospitalized with sepsis. TRIAL REGISTRATION: International Standard Randomized Control Trial Registry ISRCTN64637517.Ībstract = "ABSTRACT: INTRODUCTION: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in statin naïve patients hospitalized with sepsis. ABSTRACT: INTRODUCTION: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression.
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